Nicotinamide metabolism in mammals.
نویسندگان
چکیده
منابع مشابه
NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells
NAD+ is a vital redox cofactor and a substrate required for activity of various enzyme families, including sirtuins and poly(ADP-ribose) polymerases. Supplementation with NAD+ precursors, such as nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR), protects against metabolic disease, neurodegenerative disorders and age-related physiological decline in mammals. Here we show that nico...
متن کاملStudies on the Biosynthesis of Nicotinamide Adenine Dinucleotide. Ii. a Role of Picolinic Carboxylase in the Biosynthesis of Nicotinamide Adenine Dinucleotide from Tryptophan in Mammals.
In 1956, McDaniel, Hundley, and Sebrell (1) reported that urinary excretion of N’n~ethylnicotinamide decreased in alloxan-diabetic rats. Mehler, McDaniel, and Hundley (2) subsequently showed that the level of liver picolinic carboxylase increased markedly in alloxan-diabetic rats and was inversely related with urinary excretion of N’-methylnicotinamide. Previous nutritional studies have indicat...
متن کاملStudies on the metabolism of nicotinic acid in rabbits.
Several compounds have been described as metabolites of nicotinic acid and nicotinamide in mammals. These are nicotinic acid (I), nicotinamide (2)) nicotinuric acid (2)) trigonelline (2)) W-methylnicotinamide (NMN) (3-6)) and 1-methyl-3-carboxylamide-6-pyridone (7, 8). According to the observations of various workers mammals may be divided into two groups in so far as the metabolism of nicotini...
متن کاملNutritional Aspect of Tryptophan Metabolism
Mammals, including humans, can synthesize the vitamin nicotinamide from tryptophan in the liver. The resultant nicotinamide is distributed to non-hepatic tissues. We have studied the effects of changes in tryptophan-nicotinamide metabolism on niacin nutritional status. The liver plays a critical role in nicotinamide supply. Animal studies showed that the tryptophan-nicotinamide pathway is affec...
متن کاملNicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism.
NAD+ is a co-enzyme for hydride transfer enzymes and an essential substrate of ADP-ribose transfer enzymes and sirtuins, the type III protein lysine deacetylases related to yeast Sir2. Supplementation of yeast cells with nicotinamide riboside extends replicative lifespan and increases Sir2-dependent gene silencing by virtue of increasing net NAD+ synthesis. Nicotinamide riboside elevates NAD+ l...
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عنوان ژورنال:
- The Biochemical journal
دوره 44 1 شماره
صفحات -
تاریخ انتشار 1949